What is DADA2?


DADA2 — deficiency of the enzyme ADA2 (Adenosine Deaminase 2) — is a recently discovered and extremely rare genetic disease that usually starts in childhood. It can cause recurrent strokes, severe systemic inflammation, immune deficiency, and damage to many of the body's tissues and organs. 


Maja and Jonas Morell Thomsen tell the story of how finding the DADA2 Foundation saved their baby daughter's life. 


The first paper describing DADA2 was published in the New England Journal of Medicine in 2014. Research groups in the United States, Finland, and Israel are studying the disease. 

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We have learned from patient groups focused on other rare diseases that the most important first step is to gather information from as many patients as possible. Please help us!

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In November 2018, clinicians, researchers, and patients from around the world met for the second time in Bethesda, MD to plan a way forward for the diagnosis and treatment of DADA2. 

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Our group for patients, families, and friends is a good place to find support from families who may have been through similar experiences.

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